(&E. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. If you are already a ChemPoint customer then sign up for access to our online ordering website. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. w !1AQaq"2B #3Rbr endstream Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. 4. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Gloves, eye protection and a dust mask should be used. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . : 5. Are you looking for information about products and services by region? Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. CAS #: 9004-34-6 Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. Remove >> TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. 1 0 obj A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. 2008-2023 ChemPoint. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. Van Veen, G.K. Bolhuis, Y.S. xv}O2' H~KEe9>G/,:9\i ( The most. The table below shows the most common physicochemical parameters of this raw material. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. Manufacturer: FMC BioPolymer. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . CAS No. *r_ *?~4$ &0Y# AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. LOT #: Available upon request. Your file is uploaded and ready to be published. . Magazine: Material safety data sheet - FMC Corporation. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. 130. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. Meet our leadership team. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Micro Crystalline Cellulose. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. BIOACCUMULATIVE POTENTIAL Manufactured by: China . Avicel PC 611 Microcrystalline Cellulose. PharmaCentral 2021 . No. Material safety data sheet - FMC Corporation. q86@on$^X_HuH;3` It works as a moisture sponge and permits the controlled growth of spheroids. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. 1.3. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? 51395-75-6 Avicel RC 591. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W High performance lubricant that brings more to the tablet. No. X\o^ At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Powder becomes slippery when wet. All Rights Reserved. Looking for FMC'searnings news? These grades have particle sizes ranging from <30 to approximately 200. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. 1 0 obj Doses up to 30 g per day appear to be . : 160182 Date Approved: 05/25/2010 Revision No. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. No. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com [email protected] EMERGENCY RESPONSE NUMBER Find answers in our support articles. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. . endobj Well-recognized product that can do it all. : 9004-34-6 Date Approved: 01/31/2008 . %PDF-1.3 No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC Document(s): certificate data msds. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? << Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . POLYOX resins are nonionic polyethylene oxide solubility polymers. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL CoA. Regulatory Information /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. Microcrystalline Cellulose E460 MSDS 1. Microcrystalline cellulose is a commonly used excipient in the . bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O The short-term limit for total inhalable dust is 20 mg/m3. Avicel RC-591 & CL-611 - Description. A family of polysaccharide products that allow distinctive drug delivery solutions. % MATERIAL SAFETY DATA SHEET. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Avicel PH-101. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. In extrusion-spheronisation, it is the excipient of choice. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Alginates also function as actives in some anti-reflux products. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. 2 0 obj The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. } !1AQa"q2#BR$3br IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. It is available in different grades and particle sizes. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of .